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Updated: Aug 15, 2026

Characterizing Epithelial Wound Healing In Vivo Using the Cnidarian Model Organism Clytia hemisphaerica
Published on: February 10, 2023
An ancient control of epithelial barrier formation and wound healing
1Max-Planck-Institut fuer Entwicklungsbiologie, Tuebingen, Germany.
Abstract:
Animal epithelia are lined with apical surface matrices, which protect against pathogens, dehydration and physical damage of the underlying cells. The proteins and polysaccharides that comprise these protective barriers vary greatly within the animal kingdom and have evolved in response to the biological needs of various organisms. Yet the genetic control of barrier formation and its regeneration upon wounding appears conserved between vertebrates and insects that are evolutionary more than several hundred millions of years apart. A key role is carried out by Grainy head, a phylogenetically conserved transcription factor expressed in epidermal cells in nematodes, flies, frogs, mice and humans.
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