Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Brain MRI abnormalities in schizophrenia: same genes or same environment?

F V Rijsdijk1, N E M van Haren, M M Picchioni

  • 1Social, Genetic & Developmental Psychiatry Research Centre, Institute of Psychiatry, London, UK. f.rijsdijk@iop.kcl.ac.uk

Psychological Medicine
|September 17, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Opioid exposure on the preterm brain: qualitative and quantitative MRI analysis.

Intensive care medicine. Paediatric and neonatal·2026
Same author

Abortion care over 20 weeks gestation: a psychosocial exploration of patient experiences at the Royal Women's Hospital, Victoria, Australia.

Reproductive health·2025
Same author

Clinicians' attitudes towards the undergraduate medical student syllabus in psychiatry.

Irish journal of psychological medicine·2025
Same author

Clinical features of patients who are admitted under different criteria of the Irish Mental Health Act 2001: a retrospective cohort study.

Irish journal of psychological medicine·2025
Same author

MIR137 polygenic risk for schizophrenia and ephrin-regulated pathway: Role in lateral ventricles and corpus callosum volume.

International journal of clinical and health psychology : IJCHP·2024
Same author

The impact of fluphenazine withdrawal: a mirror-image study.

Irish journal of psychological medicine·2024
Same journal

Replicable subcortical alterations linked to neurological soft signs in schizophrenia spectrum disorders.

Psychological medicine·2026
Same journal

Distinct and common subcortical functional connectivity revealed across three major psychiatric disorders - CORRIGENDUM.

Psychological medicine·2026
Same journal

Adversity as the key feature: neuroimaging profiles of subtypes from multiple depression risk factors.

Psychological medicine·2026
Same journal

Sorting the mind: cognitive enhancement through transcutaneous auricular vagus nerve stimulation: a systematic review and meta-analysis.

Psychological medicine·2026
Same journal

Depression and aging: insights from brain age prediction models.

Psychological medicine·2026
Same journal

An integrative NLP framework identifies multilevel linguistic phenotypes of schizophrenia across tasks.

Psychological medicine·2026
See all related articles

Schizophrenia risk is linked to brain volume differences. Whole brain volume is highly heritable and genetically correlated with schizophrenia, while lateral ventricles are influenced by individual-specific environments.

Area of Science:

  • Neuroscience
  • Psychiatry
  • Behavioral Genetics

Background:

  • Structural brain volume abnormalities are key endophenotypes in schizophrenia research.
  • Understanding the genetic and environmental influences on these brain volumes is crucial.

Purpose of the Study:

  • To quantify the genetic relationship between schizophrenia and brain volumes.
  • To estimate the heritability of specific brain volumes.

Main Methods:

  • Utilized bivariate genetic model fitting on twin and sibling data.
  • Applied the model to whole brain, hippocampus, third ventricle, and lateral ventricle volumes.
  • Validated the model's unbiased estimation of heritability and correlations through simulation.

Main Results:

Related Experiment Videos

  • Whole brain volume exhibited substantial heritability (88%) and a significant genetic correlation with schizophrenia.
  • Lateral ventricles showed significant common environmental effects (67%) and an individual-specific environmental correlation with schizophrenia.
  • Hippocampus and third ventricle displayed significant familial effects, with unresolved genetic vs. environmental origins (approx. 30% each).

Conclusions:

  • Demonstrated differential sources of covariation between schizophrenia and brain volumes using genetic model fitting.
  • Identified whole brain volume's covariation with schizophrenia as primarily genetic.
  • Attributed lateral ventricle covariation with schizophrenia to individual-specific environmental factors.