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Impact of chronic phosalone toxicity on Bohr factor and oxygen equilibrium curves of rat

S J Reddy1, B V Reddy, R Ramamurthi

  • 1Pesticide and Industrial Toxicology Centre, Department of Zoology, Sri Venkateswara University, Tirupati, India.

Biochemistry International
|February 1, 1992
PubMed

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Toxicity tests in animals are grounded on two main assumptions: first, the effects observed in laboratory animals can be extrapolated to humans, especially when adjusted for body surface area; second, high-dose exposure in animals is essential to identify potential human hazards from lower doses. This is based on the quantal dose-response concept, which faces the challenge of extrapolating results from relatively few test animals to much larger human populations. For example, a 0.01% incidence...