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Updated: Aug 15, 2026

Candida albicans Biofilm Chip (CaBChip) for High-throughput Antifungal Drug Screening
Published on: July 18, 2012
A rapid screening test to distinguish between Candida albicans and Candida dubliniensis using NMR spectroscopy
Uwe Himmelreich1, Ray L Somorjai, Brion Dolenko
1Centre for Infectious Diseases and Microbiology, ICPMR, University of Sydney at Westmead Hospital, Westmead, NSW 2145, Australia. himmelreich@mpin-koeln.mpg.de
Abstract:
Nuclear magnetic resonance (NMR) spectroscopy combined with a statistical classification strategy (SCS) successfully distinguished between Candida albicans and Candida dubliniensis. 96% of the isolates from an independent test set were identified correctly. This proves that this rapid approach is a valuable method for the identification and chemotaxonomic characterisation of closely related taxa. Most discriminatory regions were correlated with metabolite profiles, indicating biochemical differences between the two species.
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