Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Blinking and schizotypal thinking.

C Mohr1, P S Sándor, T Landis

  • 1Neurology Department, University Hospital Zurich, Zurich, Switzerland. christine.mohr@bristol.ac.uk

Journal of Psychopharmacology (Oxford, England)
|September 17, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Curcumin and nano-curcumin applications in psychiatric disorders.

Phytotherapy research : PTR·2024
Same author

Dr. Mohr's Case of Cancer.

The Homoeopathic physician·2023
Same author

Swimming exercise and clove oil can improve memory by molecular responses modification and reduce dark cells in rat model of Alzheimer's disease.

Experimental gerontology·2023
Same author

Effects of an specific methodology (I Pass the Baton) on quality of handoff information among Nurses: A comparative study.

Journal of healthcare quality research·2022
Same author

1-GHz dual-comb spectrometer with high mutual coherence for fast and broadband measurements.

Optics letters·2022
Same author

The effects of Alzheimer's and Parkinson's disease on 28-day mortality of COVID-19.

Revue neurologique·2021
Same journal

Psilocybin reduces fear memory and restores neuroplasticity in the hippocampus and medial prefrontal cortex.

Journal of psychopharmacology (Oxford, England)·2026
Same journal

Classical psychedelic microdosing, mood, and cognitive function: An umbrella review with narrative synthesis.

Journal of psychopharmacology (Oxford, England)·2026
Same journal

The purpose of the psychosocial protocol in the psychedelic-assisted therapy: A scoping review.

Journal of psychopharmacology (Oxford, England)·2026
Same journal

Mitochondrial dysfunction in schizophrenia and its modulation by atypical antipsychotic drugs: A randomized controlled trial.

Journal of psychopharmacology (Oxford, England)·2026
Same journal

Effects of pimavanserin, xanomeline and highly-purified plant-derived cannabidiol on MK-801-induced behaviours in mice relevant to psychosis.

Journal of psychopharmacology (Oxford, England)·2026
Same journal

Pharmacokinetics and pharmacodynamics of orally administered S-ketamine in healthy participants.

Journal of psychopharmacology (Oxford, England)·2026
See all related articles

Spontaneous eye blink rate (SBR) may not directly reflect dopamine activity in healthy individuals. However, levodopa increased SBR in those with higher negative schizotypy, suggesting a link between dopamine and specific schizotypal traits.

Area of Science:

  • Neuroscience
  • Psychiatry
  • Pharmacology

Background:

  • Spontaneous eye blink rate (SBR) is a proposed biomarker for cerebral dopamine (DA) activity.
  • Previous research links increased SBR to positive psychotic symptoms and decreased SBR to negative psychotic symptoms.
  • Neuroleptic treatment can modulate DA systems in patient populations.

Purpose of the Study:

  • To investigate the relationship between SBR and positive/negative schizotypal traits.
  • To determine the direct influence of DA on SBR.
  • To explore how DA modulation interacts with schizotypy.

Main Methods:

  • A double-blind study involving 40 healthy men.
  • Participants received either levodopa (to increase DA) or a placebo.

Related Experiment Videos

  • SBR was measured and correlated with schizotypy scores.

    • Main Results:

    • No overall difference in SBR between levodopa and placebo groups.
    • In the levodopa group, higher SBR correlated with higher negative schizotypy scores.
    • No significant correlation between SBR and positive schizotypy was observed in either group.

    Conclusions:

    • Pharmacologically induced DA increase does not generally elevate SBR in healthy individuals.
    • Individuals with high negative schizotypy may be susceptible to DA modulation affecting SBR.
    • Distinct neural circuits might underlie SBR and positive schizotypy.