Related Experiment Video
Updated: Aug 15, 2026

Electrocardiogram Recordings in Anesthetized Mice using Lead II
Published on: June 20, 2020
Benzocaine-induced methemoglobinemia during transesophageal echocardiography
1Mercy Medical Center-North Iowa, Mason City, IA, USA. sandikayeb@hotmail.com
Abstract:
Acquired or toxic methemoglobinemia is an uncommon complication of topically administered anesthetic agents in patients of all ages-but particularly in pediatric and elderly patients. This report describes a case of acquired methemoglobinemia that occurred after benzocaine spray was applied orally to a 69-year-old white woman weighing 175 lb who was undergoing transesophageal echocardiography. Patient care was successfully managed. Fundamental concepts regarding methemoglobinemia are also reviewed to heighten physician awareness of this potentially life-threatening complication associated with the application of common topical anesthetic agents.
Insights
Topical benzocaine spray can cause acquired methemoglobinemia, a serious condition, especially in elderly or pediatric patients. Prompt recognition and management are crucial for patient safety.
Area of Science:
- Anesthesiology
- Toxicology
Background:
- Topical anesthetic agents, like benzocaine spray, are commonly used for procedures.
- Acquired methemoglobinemia is a rare but potentially life-threatening complication associated with these agents.
Observation:
- A 69-year-old woman developed acquired methemoglobinemia after oral application of benzocaine spray during a transesophageal echocardiography.
- The patient's weight was 175 lb.
Findings:
- Benzocaine-induced methemoglobinemia can occur in adults, not just pediatric patients.
- Successful patient management was achieved.
Implications:
- Heightened physician awareness of methemoglobinemia risks associated with topical anesthetics is essential.
- This case underscores the importance of recognizing and managing this adverse event promptly.
Related Concept Videos
Imaging Studies for Cardiovascular System II:Types of Echocardiography
Types of Echocardiography
Transthoracic Echocardiography (TTE)
TTE is the most common type of echocardiogram which involves placing a transducer on the patient's chest, emitting sound waves to create heart images. TTE is invaluable for evaluating the heart's size, structure, and motion, making it particularly useful for diagnosing...
Imaging Studies for Cardiovascular System I:Echocardiography
Indications: Echocardiography is utilized to diagnose heart failure, valve disorders, and myocardial infarction. It also assesses cardiac structures' size, shape, and motion, evaluates...
Effects of EDTA on End-Point Detection Methods
In the visual method, metal-ion indicators (metallochromic dyes), which have distinct colors in their free and complex forms, are added to the mixture to signal the titration's end point. They form stable complexes with metal ions, but these complexes are weaker than the corresponding metal–EDTA complexes. As a result, EDTA...

