Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Endothelial/pericyte interactions.

Annika Armulik1, Alexandra Abramsson, Christer Betsholtz

  • 1Division of Matrix Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.

Circulation Research
|September 17, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Artery-Like Smooth Muscle Drives Contractile Function in Dural Venous Sinuses.

bioRxiv : the preprint server for biology·2026
Same author

GPIHBP1 on oligodendrocytes binds lipoprotein lipase within the human brain.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

FGFR signaling establishes spatial gradients of secretory cell identities along the airway proximal-distal axis.

Nature communications·2026
Same author

Loss of meningeal lymphatic endothelial cells results in formation of a newly forming vascular network with scavenging function.

Development (Cambridge, England)·2026
Same author

Distinguishing subtypes of endothelial cells in the mouse aorta.

Proceedings of the National Academy of Sciences of the United States of America·2025
Same author

GPIHBP1, lipoprotein lipase, and triglyceride-rich lipoproteins in capillaries of the choroid plexus and circumventricular organs.

The Journal of clinical investigation·2025

Pericytes and endothelial cells are crucial for blood vessel health. Their interactions regulate vascular development and function, and failures contribute to cardiovascular defects and diseases like diabetic retinopathy.

Area of Science:

  • Vascular Biology
  • Cellular Interactions
  • Cardiovascular Science

Background:

  • Endothelial cells and mural cells (pericytes, vascular smooth muscle cells) interactions are central to vascular regulation.
  • Failures in these cell-cell interactions cause severe cardiovascular defects and are implicated in human diseases like tumor angiogenesis and diabetic microangiopathy.

Purpose of the Study:

  • To review current knowledge on pericyte identity, characteristics, diversity, ontogeny, and plasticity.
  • To focus on recent advancements in understanding intercellular communication between endothelial and mural cells.
  • To highlight the role of pericytes in specific pathological conditions.

Main Methods:

  • Literature review of recent scientific publications.
  • Focus on key signaling pathways: TGF-β, angiopoietins, PDGF, S1P, and Notch.

Related Experiment Videos

  • Analysis of data related to pericyte involvement in disease models.

    • Main Results:

    • Pericytes are diverse cells with significant plasticity.
    • Intercellular communication pathways involving specific growth factors and ligands are critical for vascular homeostasis.
    • Pericytes play significant roles in tumor angiogenesis, diabetic retinopathy, and hereditary lymphedema.

    Conclusions:

    • Understanding pericyte biology and their interactions with endothelial cells is vital for addressing vascular diseases.
    • Targeting these interactions offers potential therapeutic strategies for conditions like cancer and diabetes.
    • Further research into pericyte plasticity and signaling is warranted.