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Updated: Aug 15, 2026
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Permanent Cerebral Vessel Occlusion via Double Ligature and Transection
Published on: July 21, 2013
One-stage anterior approach for four-vessel occlusion in rat
Mitsuo Yamaguchi1, John W Calvert, Gen Kusaka
1Department of Neurosurgery, Louisiana State University Health Sciences Center, Shreveport, USA.
Stroke
|September 17, 2005
Abstract
Background And Purpose:
We report a modified 4-vessel occlusion (4VO) rat model.
Method:
We used a 1-stage anterior approach for making bilateral hemispheric ischemia.
Results:
Modified 4VO method decreased cerebral blood flow to 12% to 14% of baseline levels.
Conclusions:
This modified 4VO method is a minimally invasive, quick, reliable procedure for producing ischemic changes.
