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Culture of Macrophage Colony-stimulating Factor Differentiated Human Monocyte-derived Macrophages
Published on: June 30, 2016
Serum level of macrophage colony-stimulating factor and atherosclerosis in hemodialysis patients
Kazutaka Haraguchi1, Masashi Kubo, Takehiro Saito
13rd Department of Internal Medicine, University of Yamanashi, Kofu, Japan. kazutaka@swallow.res.yamanashi-med.ac.jp
Insights
Macrophage colony-stimulating factor (MCSF) is linked to atherosclerosis markers like intima-media thickness (IMT) and aortic calcification index (ACI) in hemodialysis (HD) patients. MCSF showed a stronger association than high-sensitivity C-reactive protein (hsCRP).
Area of Science:
- Cardiovascular Medicine
- Nephrology
- Biomarkers
Background:
- Atherosclerosis is a primary cause of mortality in hemodialysis (HD) patients.
- Aortic calcification index (ACI), intima-media thickness (IMT), and ECG are key atherosclerotic indicators.
- Macrophage colony-stimulating factor (MCSF) and monocyte chemoattractant protein-1 (MCP-1) are implicated in atherosclerosis.
Purpose of the Study:
- To investigate the association between serum MCSF, MCP-1 levels, and atherosclerotic parameters (ACI, IMT, ECG) in HD patients.
- To compare the association of MCSF and high-sensitivity C-reactive protein (hsCRP) with IMT and ACI.
Main Methods:
- Cross-sectional study of 133 maintenance HD outpatients.
- Serum MCSF and MCP-1 levels were measured.
- ACI was determined by computed tomography; IMT by high-sensitivity ultrasound; ECGs were performed.
Main Results:
- MCSF levels correlated with age-adjusted IMT and diastolic blood pressure.
- MCSF and age were independently associated with increased ACI.
- hsCRP correlated with ECG changes, while MCSF showed a weaker association; MCP-1 was not significantly related to these parameters.
Conclusions:
- MCSF is significantly associated with IMT and ACI in HD patients.
- MCSF demonstrates a stronger association with IMT and ACI compared to hsCRP.
- These findings highlight MCSF as a potential biomarker for atherosclerosis in the HD population.
Background/Aims:
Atherosclerosis and its related complications are the leading causes of death in the hemodialysis (HD) population. Aortic calcification index (ACI), intima-media thickness (IMT) in common carotid arteries, and electrocardiogram (ECG) are atherosclerotic parameters that are available in usual clinical outpatient settings. Macrophage colony-stimulating factor (MCSF) and monocyte chemoattractant protein-1 (MCP-1) play important roles in atherosclerosis.
Methods:
We performed a cross-sectional study of 133 outpatients on maintenance HD in a single HD outpatient center. We measured serum levels of MCSF and MCP-1, determined the ACI using computed tomography scan and the IMT using high-sensitivity ultrasound B-mode imaging, and performed ECGs.
Results:
Stepwise multivariate regression analysis revealed that the MCSF level correlated with age-adjusted mean and maximum IMT (F = 10.811, p = 0.001, and F = 6.784, p = 0.010, respectively) as well as with the diastolic blood pressure. Age and MCSF level (F = 4.866, p = 0.029) were independently related to an increased ACI. High-sensitivity C-reactive protein (hsCRP) was not related to IMT and ACI. The hsCRP level (chi2 = 5.002, p = 0.025) correlated with ECG changes followed by MCSF (chi2 = 3.940, p = 0.047). MCP-1 was not related to the above atherosclerotic parameters.
Conclusion:
A head-to-head comparison between MCSF and hsCRP revealed that MCSF was more closely associated with IMT and ACI in HD patients.
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