Tumor lysis syndrome: pathophysiology, definition, and alternative treatment approaches
Gustavo Del Toro1, Erin Morris, Mitchell S Cairo
1Division of Pediatric Hematology, Columbia University, 180 Fort Washington Avenue, New York, NY 10032, USA.
Clinical Advances in Hematology & Oncology : H&O
|September 17, 2005
Abstract:
Tumor lysis syndrome (TLS), a life threatening metabolic syndrome seen in malignancies with high tumor burden, is reviewed in this article. The new Cairo and Bishop classification system is discussed as well as the clinical management of this syndrome. Special emphasis is placed on the use of a relatively new agent, rasburicase, as an alternative to allopurinol in the management of TLS-associated hyperuricemia.
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