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Discovery of Driver Genes in Colorectal HT29-derived Cancer Stem-Like Tumorspheres

Discovery of Driver Genes in Colorectal HT29-derived Cancer Stem-Like Tumorspheres

Published on: July 22, 2020

[Growth hormone receptor expression in human colorectal cancer and its implication]

Xiao-dong Yang¹, Fu-kun Liu, Zhe Xu

¹Research Institute of General Surgery, Nanjing General Hospital of PLA, Nanjing 210002, China. yangxd96@hotmail.com

Zhonghua Wei Chang Wai Ke Za Zhi = Chinese Journal of Gastrointestinal Surgery

|September 17, 2005

Abstract

Objective:

To investigate the role of the expression of growth hormone receptor (GHR) in the development and progression of human colorectal cancer (CRC).

Methods:

The expression levels of GHR and Ki-67 were detected by immunohistochemistry technique in CRC specimens and normal mucous tissue from 100 patients with CRC. The association between expression of GHR and clinicopathological factors was analyzed.

Results:

The expression of GHR was higher in the colorectal cancerous tissue compared to the normal mucous tissue (81% vs. 68%). The expression of GHR was significantly correlated with pathological staging (P=0.047), tumor differentiation (P=0.003) and tumor size (P=0.017). The expression of GHR was significantly associated with the expression of Ki-67 (P< 0.01) as well as tumor proliferation (P< 0.01).

Conclusion:

The over-expression of GHR is shown in human colorectal cancer and it also plays an important role in the development of human colorectal cancer. The use of rhGH in clinic should be cautious.

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