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Eight years' experience with an IVF surrogate gestational pregnancy programme
Arieh Raziel1, Morey Schachter, Deborah Strassburger
1Infertility and IVF Unit, Assaf Harofeh Medical Centre, Tel-Aviv University, Zerifin, 70300, Israel. araziel@012.net.il
Reproductive Biomedicine Online
|September 20, 2005
Summary
The presence or absence of a uterus in commissioning mothers does not impact in vitro fertilization (IVF) performance or conception rates in surrogacy. Success depends on factors beyond uterine presence, potentially an "oocyte factor" in challenging cases.
Area of Science:
- Reproductive Medicine
- Assisted Reproductive Technology
Background:
- Surrogacy is utilized for various infertility reasons, including uterine absence and repeated in vitro fertilization (IVF) failure.
- Comparing outcomes in surrogacy based on indication is crucial for understanding success factors.
Purpose of the Study:
- To compare IVF and pregnancy outcomes in surrogacy for uterine absence versus other indications.
- To evaluate the impact of the commissioning mother's uterine status on IVF success.
Main Methods:
- Retrospective audit of 60 IVF surrogate cycles over eight years.
- Comparison of two groups: Group A (uterine absence) and Group B (other indications like IVF failure, recurrent abortions).
- Analysis of ovarian stimulation, IVF performance, and pregnancy rates.
Main Results:
- No significant difference in ovarian stimulation or IVF performance between groups.
- Higher pregnancy rates per patient (70% vs 33%) and per transfer (20% vs 12%) observed in Group A.
- A median of three cycles was needed for pregnancy, suggesting potential 'oocyte factors' in prolonged cases.
Conclusions:
- The presence or absence of a uterus in commissioning mothers is irrelevant to IVF performance and conception rates.
- Success in surrogacy is not dictated by the commissioning mother's uterine status.
- An 'oocyte factor' may influence conception rates in patients requiring multiple IVF cycles.