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Published on: April 3, 2014
Dinuclear macrocyclic polyamine zinc(II) complexes linked with flexible spacers: synthesis, characterization, and DNA
Wei Peng1, Pei-Yan Liu, Ning Jiang
1Department of Chemistry, Key Laboratory of Green Chemistry and Technology ,Ministry of Education, Sichuan University, 29 Wangjiang Road, Chengdu, Sichuan 610064, PR China.
Abstract:
Dinuclear macrocyclic polyamine zinc(II) complexes, which have two cyclen groups linked by flexible spacers, have been synthesized as DNA cleavage agents. The structures of these new dinuclear complexes are consistent with the data obtained from elemental analysis, MS and 1H NMR spectroscopy. The catalytic activity of these dinuclear complexes on DNA cleavage was studied. The results showed that the dinuclear zinc(II) complexes can catalyze the cleavage of supercoiled DNA (pUC 19 plasmid DNA) (Form I) under physiological conditions to produce selectively nicked DNA (Form II).
