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Yeast As a Chassis for Developing Functional Assays to Study Human P53
Published on: August 4, 2019
Germline polymorphism of p53 codon 72 in gynecological cancer
Masatsugu Ueda1, Yoshito Terai, Koji Kanda
1Department of Obstetrics and Gynecology, Osaka Medical College, 2-7 Daigakumachi, Takatsuki Osaka 569-8686, Japan. gyn017@poh.osaka-med.ac.jp
Objective:
To investigate the biological significance of single nucleotide polymorphism at codon 72 of the p53 gene in the development of gynecological cancer.
Methods:
p53 codon 72 polymorphism was examined in a total of 354 blood samples from 95 normal, 83 cervical, 108 endometrial and 68 ovarian cancer cases using polymerase chain reaction and restriction fragment length polymorphism techniques.
Results:
When p53 codon 72 genotype was classified into two subgroups of Arg/Arg and Arg/Pro + Pro/Pro, the Arg/Arg genotype was associated with an increased risk for the development of endometrial cancer (OR = 1.86, 95% CI = 1.06 to 3.26) compared with the Arg/Pro + Pro/Pro genotype (P = 0.0301). The Arg allele also increased the risk of endometrial cancer (OR = 1.42, 95% CI = 0.93 to 1.52) compared with the Pro allele, but no statistical difference was found (P = 0.1031). There was no significant difference in the genotype or allele prevalence between control subjects and cervical or ovarian cancer patients.
Conclusion:
Homozygous Arg at codon 72 of the p53 gene may be a risk factor for developing endometrial cancer in a Japanese population.
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