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Calciuria and preeclampsia: a case-control study
Valérie Szmidt-Adjidé1, Françoise Vendittelli, Sandra David
1Service de Biochimie, Centre Hospitalier Universitaire de Guadeloupe, Pointe-à-Pitre, Guadeloupe, French West Indies.
European Journal of Obstetrics, Gynecology, and Reproductive Biology
|September 20, 2005
Summary
Preeclamptic pregnant women exhibit significantly lower urinary calcium excretion (calciuria) compared to healthy controls. This finding, termed hypocalciuria, is a strong indicator for preeclampsia in this population.
Area of Science:
- Obstetrics and Gynecology
- Nephrology
- Clinical Chemistry
Background:
- Preeclampsia is a serious pregnancy complication.
- Urinary calcium excretion (calciuria) may be altered in preeclampsia.
Purpose of the Study:
- To compare calciuria in preeclamptic women versus normotensive controls.
- To investigate hypocalciuria as a potential biomarker for preeclampsia.
Main Methods:
- Case-control study involving 47 preeclamptic women and 50 controls.
- Measured 24-hour urinary calcium excretion and serum markers.
- Logistic regression analysis adjusted for clinical factors.
Main Results:
- Preeclamptic women showed significantly lower calciuria (1.5 vs. 6.0 mmol/24h).
- Hypocalciuria strongly associated with preeclampsia (Adjusted Odds Ratio=21.74).
- Calciuria < 2.1 mmol/24h had high negative predictive value (97%).
Conclusions:
- Preeclamptic women in this population have significantly reduced calciuria.
- Hypocalciuria is a significant indicator associated with preeclampsia.