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Related Experiment Videos

[Thoracic adenoid cystic carcinomas].

C Le Péchoux1, P Baldeyrou, I Ferreira

  • 1Service de radiothérapie, institut Gustave-Roussy, 39, rue Camille-Desmoulins, 94000Villejuif, France. lepechoux@igr.fr

Cancer Radiotherapie : Journal De La Societe Francaise De Radiotherapie Oncologique
|September 20, 2005
PubMed
Summary

Adenoid cystic carcinomas, a rare tracheal tumor, are often diagnosed late due to slow growth. Treatment involves surgery and radiotherapy, with survival rates varying by stage and treatment approach.

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Area of Science:

  • Oncology
  • Pulmonology
  • Pathology

Context:

  • Adenoid cystic carcinomas (ACCs) are rare but constitute approximately 40% of all tracheal tumors.
  • These tumors exhibit slow growth, frequently leading to diagnosis at advanced stages.
  • Intrathoracic localizations include the carena and proximal airways.

Purpose:

  • To review the characteristics, diagnosis, and treatment of adenoid cystic carcinomas in the trachea.
  • To discuss the role of surgery and radiotherapy in managing limited and inoperable tracheal tumors.
  • To highlight survival rates and future therapeutic considerations for advanced or recurrent disease.

Summary:

  • Pathological identification of tracheal ACCs can be challenging.
  • Treatment for localized tumors typically involves surgical resection, often combined with radiotherapy, with doses ranging from 45 to 65 Gy based on margin status.

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  • For inoperable cases, exclusive radiotherapy exceeding 60 Gy is recommended, though survival rates are lower (12-27%) in heterogeneous patient groups.

    • Impact:

    • Surgery combined with postoperative radiotherapy yields 5-year survival rates of 65-80% for localized tracheal ACCs.
    • Effective radiotherapy doses are crucial for improving outcomes in both operable and inoperable tracheal tumors.
    • Future research into targeted therapies is warranted due to the chemo-resistant nature and late recurrence patterns of ACCs.