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The lineage relationship between virgin and memory B cells.

X M Yin1, E S Vitetta

  • 1Department of Microbiology, University of Texas Southwestern Medical Center, Dallas 75235.

International Immunology
|June 1, 1992
PubMed
Summary
This summary is machine-generated.

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Memory B cell precursors are identified as J11d-low B cells. These J11d-low B cells, distinct from J11d-high B cells, develop into memory B cells, crucial for adaptive immunity.

Area of Science:

  • Immunology
  • Cell Biology

Background:

  • J11d is expressed on hemopoietic cells, including B cells.
  • B cells exhibit heterogeneity in J11d expression, with memory B cells found in the J11d-low population.

Purpose of the Study:

  • To investigate the relationship between B cell memory precursors and memory cells.
  • To elucidate the role of J11d expression levels in B cell differentiation and memory formation.

Main Methods:

  • Adoptive transfer of J11d-low and J11d-high B cells from unprimed mice into irradiated recipients.
  • Antigenic stimulation and in vitro culture.
  • Analysis of primary and memory responses.
  • Flow cytometry to assess J11d expression levels.

Main Results:

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  • J11d-low B cells from unprimed mice showed limited primary responses but generated robust memory responses after adoptive transfer and stimulation.
  • J11d-high B cells from unprimed mice produced both primary and memory responses, but the latter were less potent than those from J11d-low cells.
  • J11d-low virgin B cells proliferated more rapidly than J11d-high virgin B cells post-transfer, suggesting a role in memory development.

Conclusions:

  • Memory B cell responses are predominantly generated from J11d-low virgin B cells.
  • J11d-low B cells are distinct from J11d-high B cells and represent either memory precursors or established memory cells.