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Schizotypal dimensions: continuity between schizophrenia and bipolar disorders
Franck Schürhoff1, Audrey Laguerre, Andreï Szöke
1Département hospitalo-universitaire de Psychiatrie, Hôpital Albert Chenevier et Henri Mondor (AP-HP), 40 rue Mesly, 94000 Créteil, France. schurhof@ext.jussieu.fr
Schizophrenia Research
|September 20, 2005
Summary
The disorganization dimension of schizotypal personality disorder (SPD) is shared between relatives of schizophrenia and psychotic bipolar disorder patients, indicating a common genetic basis for these conditions. The negative dimension of SPD is familial but does not increase the risk for these disorders.
Area of Science:
- Psychiatry
- Genetics
- Psychology
Background:
- Schizophrenia and bipolar disorders may share genetic susceptibility factors.
- Schizotypal personality disorder (SPD) could be an intermediate phenotype linking these disorders.
- Familiality of schizotypal dimensions requires further investigation.
Purpose of the Study:
- To explore the familiality of schizotypal dimensions.
- To compare schizotypal dimensions in relatives of schizophrenia and bipolar probands.
- To assess the familial risk associated with specific schizotypal dimensions.
Main Methods:
- Utilized the Schizotypal Personality Questionnaire (SPQ) in unaffected first-degree relatives.
- Studied three dimensions: disorganization, negative, and positive.
- Employed t-tests, ANOVA, chi-squared tests, intraclass correlation, and linear mixed models.
Main Results:
- The disorganization dimension was common in relatives of schizophrenia and psychotic bipolar probands.
- Disorganization dimension increased familial risk for schizophrenia and psychotic bipolar disorders.
- The negative dimension showed intra-familial resemblance (R=0.29) but no increased familial risk.
Conclusions:
- Shared disorganization dimension suggests a common genetic background for psychotic disorders.
- Familial risk for schizophrenia and psychotic bipolar disorders is linked to the disorganization dimension.
- While familial, the negative dimension is not associated with increased risk for these disorders.