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Disc vascularity in Down's syndrome.

M C Sherk, T D Williams

    American Journal of Optometry and Physiological Optics
    |August 1, 1979
    PubMed
    Summary
    This summary is machine-generated.

    Patients with Down syndrome have increased large blood vessels at the optic nerve head. This study compared ocular fundus photographs of 100 Down syndrome patients to 100 normal individuals, revealing significant vascular differences in the optic nerve head.

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    Area of Science:

    • Ophthalmology
    • Genetics
    • Vascular Biology

    Background:

    • Down syndrome is associated with various ocular abnormalities.
    • Optic nerve head (ONH) vascularity is crucial for retinal health.
    • Previous research on ONH vascularity in Down syndrome is limited.

    Purpose of the Study:

    • To investigate and quantify the vascularity of the optic nerve head in individuals with Down syndrome.
    • To compare ONH vascular patterns between Down syndrome patients and a normal control group.

    Main Methods:

    • Ocular fundus photographs were obtained from 100 institutionalized patients with Down syndrome (66 males, 34 females).
    • Vascularity of the optic nerve head was assessed by counting arterioles, venules, and fine vessels crossing the disc margin.

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  • Data were compared to similar measurements from 100 normal individuals.

    • Main Results:

    • Individuals with Down syndrome exhibited a greater number of large vessels crossing the optic disc margin compared to normal controls.
    • The analysis revealed distinct differences in optic nerve head vascular patterns between the two groups.

    Conclusions:

    • The optic nerve head in individuals with Down syndrome demonstrates altered vascularity, characterized by an increase in large vessels.
    • These findings contribute to understanding the ocular manifestations of Down syndrome and may have implications for ophthalmic care.