Related Experiment Video
Updated: Aug 15, 2026

Uptake of New Lipid-coated Nanoparticles Containing Falcarindiol by Human Mesenchymal Stem Cells
Published on: February 9, 2019
Polycationic lipophilic-core dendrons as penetration enhancers for the oral administration of low molecular weight
Patricia Y Hayes1, Benjamin P Ross, Bradley G Thomas
1Discipline of Chemistry, School of Molecular and Microbial Sciences, and School of Pharmacy, The University of Queensland, Brisbane, Queensland 4072, Australia.
Abstract:
Two polycationic lipophilic-core carbohydrate-based dendrons 2a-b and five polycationic lipophilic-core peptide dendrons 3-6, containing four arginine or lysine terminal residues, were synthesized and then tested in rats as penetration enhancers for the oral delivery of low molecular weight heparin. Better results were obtained with dendrons containing terminal lysine residues than terminal arginine. A significant anti-factor Xa activity was obtained when low molecular weight heparin was coadministered with dendron 5.
Related Concept Videos
Anticoagulant Drugs: Low-Molecular-Weight Heparins
Bioavailability Enhancement: Drug Permeability Enhancement
Site-Targeted Drug Delivery Systems: Polymeric Carriers
Oral Drug Delivery Systems: Delayed-Release Systems
Oral Drug Delivery Systems: Introduction
Drug Delivery: Parenteral Route
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...

