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Synthesis and Bioconjugation of Thiol-Reactive Reagents for the Creation of Site-Selectively Modified Immunoconjugates
Published on: March 6, 2019
Solid support synthesis of 6-aryl-2-substituted pyrimidin-4-yl phenols as anti-infective agents
Anu Agarwal1, Kumkum Srivastava, S K Puri
1Division of Medicinal & Process Chemistry, Central Drug Research Institute, Lucknow 226001, India.
Abstract:
A library of 30 trisubstituted pyrimidines were synthesized and evaluated for their in vitro antimalarial and antitubercular activity. Out of the 30 compounds synthesized, 23 compounds have shown in vitro antimalarial activity against Plasmodium falciparum in the range of 0.25-2 microg/mL and 16 compounds have shown antitubercular activity against Mycobacterium tuberculosis H37Ra, at a concentration of 25 microg/mL.
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