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Topical ciclosporin in the treatment of ocular surface disorders

S Tatlipinar1, E K Akpek

  • 1The Wilmer Eye Institute, Johns Hopkins School of Medicine, Baltimore, MD 21287-9238, USA.

The British Journal of Ophthalmology
|September 20, 2005
PubMed

Insights

Inflammation drives ocular surface diseases. Topical ciclosporin, an immunomodulator, offers a new treatment option, prompting a review of its established uses and future research directions.

Area of Science:

  • Ophthalmology
  • Immunology
  • Inflammation

Background:

  • Inflammation is central to ocular surface disease pathogenesis.
  • Current treatments like topical corticosteroids have side effects.
  • Ciclosporin A is an immunomodulator inhibiting T lymphocyte proliferation.

Purpose of the Study:

  • Provide an overview of established ciclosporin uses in ophthalmology.
  • Discuss the role of ciclosporin in ocular surface diseases.
  • Identify future research questions regarding topical ciclosporin.

Main Methods:

  • Literature review of ciclosporin A in ocular surface diseases.
  • Analysis of clinical data and research on topical ciclosporin preparations.
  • Synthesis of information on immunomodulatory effects and therapeutic applications.

Main Results:

  • Topical ciclosporin A is now FDA-approved for ophthalmic use.
  • Ciclosporin A specifically targets T lymphocyte proliferation.
  • Established uses and emerging applications in managing ocular inflammation.

Conclusions:

  • Topical ciclosporin represents a significant advancement in treating ocular surface diseases.
  • Further research is needed to fully elucidate its long-term efficacy and safety profile.
  • Understanding ciclosporin's role is crucial for managing complex inflammatory eye conditions.

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