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Related Experiment Video

Updated: Jul 18, 2026

Assessment of Cocaine-induced Behavioral Sensitization and Conditioned Place Preference in Mice

Assessment of Cocaine-induced Behavioral Sensitization and Conditioned Place Preference in Mice

Published on: February 18, 2016

Cocaine-induced conditioned taste avoidance over extended conditioned stimulus-unconditioned stimulus intervals.

K B Freeman¹, A L Riley

¹Psychopharmacology Laboratory, Department of Psychology, American University, Washington, DC 20016, USA. kf6802a@american.edu

Behavioural Pharmacology

|September 20, 2005

Summary

Long-delay learning in taste avoidance conditioning is not limited to emetic compounds. Cocaine, a non-emetic drug, also supports this learning, suggesting it

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Area of Science:

Neuroscience
Behavioral Psychology
Pharmacology

Background:

Long-delay learning in conditioned taste avoidance (CTA) is well-documented, but primarily with emetic unconditioned stimuli.
Non-emetic compounds, including drugs of abuse, can also induce CTA.

Purpose of the Study:

To investigate if cocaine, a non-emetic psychoactive drug, can support long-delay conditioning in a CTA paradigm.

Main Methods:

Rats received saccharin (conditioned stimulus) paired with cocaine (unconditioned stimulus) at various delays (10-540 min).
Two conditioning trials were followed by six extinction trials.
A control group received a vehicle injection.

Main Results:

All cocaine-treated groups showed significantly reduced saccharin consumption compared to controls.
The magnitude of taste avoidance decreased as the conditioned stimulus-unconditioned stimulus interval increased.
Avoidance persisted even after extinction trials for shorter intervals (10, 60, 120 min).

Conclusions:

Cocaine supports long-delay taste avoidance learning, extending beyond emetic compounds.
Long-delay learning appears to be a general characteristic of CTA, not specific to emetics.