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A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development
08:50

A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development

Published on: June 24, 2020

Perinatal inflammation and infection

L Cornette1

  • 1Peter Congdon Neonatal Unit, Leeds General Infirmary, Leeds, UK. luc.cornette@leedsth.nhs.uk

Minerva Ginecologica
|September 20, 2005
PubMed

Insights

Fetal and neonatal inflammation are linked to adverse neurodevelopmental outcomes. More research is needed to identify inflammatory risk profiles and develop new anti-inflammatory interventions for newborns.

Area of Science:

  • Perinatal medicine
  • Neonatology
  • Neuroscience

Background:

  • Feto-maternal and neonatal inflammatory/infective processes are common.
  • These processes are associated with neonatal morbidities like chronic lung disease and necrotising enterocolitis.
  • Genetic and environmental factors modulate these inflammatory responses.

Purpose of the Study:

  • To review the relationship between perinatal inflammation and neonatal (neuro)morbidity.
  • To investigate the interaction of inflammatory processes with genetic and environmental factors.
  • To highlight the need for further research into preventative strategies.

Main Methods:

  • Literature review of existing evidence.
  • Analysis of the link between perinatal inflammatory responses and neonatal neurodevelopmental outcomes.
  • Discussion of current limitations and future research directions.

Main Results:

  • No single intervention currently prevents impaired neurodevelopment following fetal/neonatal inflammation.
  • A complex interplay exists between inflammatory processes, genetic, and environmental factors.
  • Current evidence suggests a significant association between perinatal inflammation and neonatal neurodevelopmental issues.

Conclusions:

  • There is a critical need for advanced epidemiological studies with long-term follow-up.
  • Future research should focus on identifying pre- and postnatal inflammatory risk profiles.
  • Clarifying the relationship between inflammation markers and their temporal expression in fetal/neonatal circulation is crucial for developing novel anti-inflammatory interventions.

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