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Related Experiment Videos

Pervasive adaptive evolution in primate seminal proteins.

Nathaniel L Clark1, Willie J Swanson

  • 1Department of Genome Sciences, University of Washington, Seattle, Washington, USA. clarknl@u.washington.edu

Plos Genetics
|September 20, 2005
PubMed
Summary
This summary is machine-generated.

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Primate seminal fluid proteins, crucial for reproduction and defense, show significant adaptive evolution. This study reveals positive selection in seven key proteins, highlighting evolutionary pressures across diverse species.

Area of Science:

  • Evolutionary biology
  • Genomics
  • Reproductive science

Background:

  • Seminal fluid proteins play vital roles in reproduction, influencing female physiology and behavior, sperm competition, and pathogen defense.
  • Adaptive pressures are expected due to sexual selection and host defense, but the extent of positive selection in seminal fluid proteins across different species remains largely unknown.

Purpose of the Study:

  • To identify adaptive evolution in primate seminal fluid proteins using genomic data.
  • To investigate the extent of positive selection in these proteins across divergent primate species.

Main Methods:

  • Comparative genomic analysis of 161 human seminal fluid proteins and 2,858 prostate-expressed genes against chimpanzee counterparts.
  • Tissue-specific genomic resource utilization.

Related Experiment Videos

  • Divergent evolutionary analysis of selected genes in primates.

    • Main Results:

    • Extensive signatures of positive selection were found in primate seminal fluid proteins when compared to prostate-expressed genes.
    • Seven out of eight outstanding genes showed statistically significant evidence of positive selection across divergent primates.
    • Species-specific loss of function in copulatory plug genes and spatial clustering of selected sites near kallikrein 2's active site were observed.

    Conclusions:

    • This study reveals previously unidentified positive selection in seven primate seminal proteins.
    • The findings, consistent with studies in Drosophila, suggest extensive positive selection in seminal fluid proteins across diverse taxonomic groups, driven by reproductive and defense functions.