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Related Experiment Videos

Pneumococcal antimicrobial resistance: the problem in Hungary.

A Marton1

  • 1Heim Pál Children's Hospital, Budapest, Hungary.

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
|July 1, 1992
PubMed
Summary

Penicillin resistance in Streptococcus pneumoniae reached 58% in Hungary (1988-1989), with higher rates in children. Penicillin-resistant strains showed cross-resistance to other antibiotics, but ceftriaxone and cefotaxime offer therapeutic promise.

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Area of Science:

  • Microbiology
  • Epidemiology
  • Infectious Diseases

Background:

  • Penicillin resistance in Streptococcus pneumoniae is a growing public health concern.
  • Understanding resistance patterns is crucial for effective antibiotic therapy.

Purpose of the Study:

  • To determine the prevalence of penicillin resistance in Streptococcus pneumoniae in Hungary.
  • To assess the susceptibility of resistant strains to other antibiotics.
  • To evaluate the potential of alternative antibiotics for treating infections caused by resistant strains.

Main Methods:

  • Epidemiological survey of Streptococcus pneumoniae isolates from Hungarian laboratories (1988-1989).
  • Determination of minimum inhibitory concentrations (MICs) for penicillin and other antibiotics.

Related Experiment Videos

  • Comparison of resistance rates between pediatric and adult patient isolates.

    • Main Results:

    • A 58% prevalence of penicillin resistance was observed in 135 Streptococcus pneumoniae isolates.
    • Pediatric isolates exhibited a significantly higher resistance rate (69.2%) compared to adult isolates (44.0%).
    • Penicillin-resistant strains demonstrated higher co-resistance to tetracycline, erythromycin, co-trimoxazole, and chloramphenicol.

    Conclusions:

    • Ampicillin and cephalexin showed no superiority over penicillin against resistant strains.
    • Ceftriaxone and cefotaxime demonstrated low MIC90 values, indicating potential therapeutic value for severe infections.
    • Second-generation cephalosporins like cefuroxime or cefamandole may serve as alternatives for respiratory tract infections.