Macrophage and Leishmania: an unacceptable coexistence

Research over the past year has revealed several significant and interesting advances in the biology of macrophage, key cells responsible in body's host defense against invading pathogens and in immune responses. Perturbation of macrophage surface with different bacterial pathogens leads to activate general signal transduction pathways of macrophages, including activation of NADPH oxidase, nitric oxide synthase, and so on. However, in this review, the results of macrophage interactions only with Leishmania parasites, which harbors the host macrophages, are discussed. It appears that interference in transduction of regulatory signals during leishmanial invasion lead to an inadequate leishmanicidal response. In this connection, information concerning regulation of MHC molecules and other current events related to macrophage function after invasion by the parasites are also discussed.