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Updated: Aug 15, 2026
Induction of Drug-Induced, Autoimmune Hepatitis in BALB/c Mice for the Study of Its Pathogenic Mechanisms
Published on: May 29, 2020
Sleep during concanavalin-A-induced hepatitis and peritonitis in inbred mice
Linda A Toth1, Larry F Hughes, Jerold E Rehg
1Department of Pharmacology, Southern Illinois University School of Medicine, Springfield, IL 62794-9611, USA. ltoth@siumed.edu
Study Objectives:
To assess the suitability of concanavalin-A-induced hepatitis as a model for investigating the relationships between hepatic disease and alterations in somnolence.
Design:
We characterized the sleep patterns of various strains of inbred mice undergoing ConA-induced inflammation.
Setting:
Southern Illinois University School of Medicine, Springfield, IL.
Intervention:
Intravenous or intraperitoneal administration of concanavalin-A.
Participants:
Inbred mice.
Measurements And Results:
Intravenous and intraperitoneal administration of concanavalin-A both elicited strain-dependent changes in slow-wave sleep. ConA treatment also reduced spontaneous locomotor activity. ConA-induced changes in slow-wave sleep varied with dose, route of administration, and circadian period of administration. As compared with the other strains, C57BL/6J mice had lower serum concentrations of interferon-gamma at 8 hours after ConA administration.
Conclusions:
These data provide the first demonstration that sleep enhancement and reduced locomotor activity accompany hepatic inflammation in mice.
