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Related Experiment Videos

Spongiform encephalopathies in Cervidae.

E S Williams1, S Young

  • 1Department of Veterinary Sciences, University of Wyoming, Laramie 82070.

Revue Scientifique Et Technique (International Office of Epizootics)
|June 1, 1992
PubMed
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Experimental transmission of chronic wasting disease (CWD) of elk (Cervus elaphus nelsoni), white-tailed deer (Odocoileus virginianus), and mule deer (Odocoileus hemionus hemionus) to white-tailed deer by intracerebral route.

Veterinary pathology·2008

Chronic Wasting Disease (CWD), a transmissible spongiform encephalopathy, affects wild ruminants like deer and elk. It is not foodborne but spreads through animal contact, posing future concerns for wildlife and farming.

Area of Science:

  • Veterinary Neurology
  • Wildlife Pathology
  • Prion Diseases

Background:

  • Transmissible spongiform encephalopathies (TSEs) are expanding their host range to wild ruminants.
  • Chronic Wasting Disease (CWD) is a notable TSE affecting cervids (deer and elk) in North America.
  • CWD cases have been observed in both captive and free-ranging animals.

Purpose of the Study:

  • To describe the clinical and pathological features of Chronic Wasting Disease (CWD) in wild ruminants.
  • To differentiate CWD from other spongiform encephalopathies, particularly those linked to Bovine Spongiform Encephalopathy (BSE).
  • To discuss the transmission dynamics and potential future implications of CWD.

Main Methods:

  • Clinical observations of affected mule deer and Rocky Mountain elk.

Related Experiment Videos

  • Pathological examination of central nervous system tissues.
  • Histopathological analysis for spongiform change, vacuolation, astrocytosis, and amyloid plaques.

    • Main Results:

    • Clinical signs include progressive weight loss, behavioral changes, and excessive salivation; deer also exhibit polydipsia and polyuria.
    • Neuropathological findings are confined to the CNS, characterized by spongiform change, neuronal vacuolation, astrocytosis, and amyloid plaques without inflammation.
    • CWD transmission is not linked to foodborne exposure like BSE but appears to occur via lateral and possibly maternal contact in captive populations.

    Conclusions:

    • CWD is a distinct spongiform encephalopathy in wild cervids, differing from BSE-related encephalopathies in bovids.
    • The disease is maintained through animal-to-animal transmission within populations.
    • While currently geographically limited, CWD poses a potential future threat due to wildlife trade and game farming expansion.