The direct effect of light therapy on endothelial cell proliferation in vitro

During repair, new blood vessels are formed by the process of angiogenesis. The prerequisite to blood vessel formation is the proliferation of endothelial cells. The purpose of this study was to find out if light therapy is capable of affecting endothelial cell proliferation in vitro. The direct effect of light at wavelengths of either 660 or 820 nm was studied on primary cultures of bovine aortic endothelial cells using varying energy densities, of either 1, 2, 4, or 8 J/cm2. The proliferation of the endothelial cells was assessed over a period of five days after a single irradiation.