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Chromosomal analysis of pregnancy losses in patients undergoing assisted reproduction
L E Shields1, P C Serafini, R S Schenken
1Department of Obstetrics and Gynecology, University of Texas Health Science Center, San Antonio 78284-7836.
Abstract:
Chromosomal analysis was performed on products of conception from 18 patients having early pregnancy loss after assisted reproduction. Sonographic findings prior to obtaining tissue varied from gestational sacs consistent with a blighted ovum to fetal poles with cardiac activity. The mean age of the patients was 36.3 years. There were nine (50%) normal karyotypes, five (28%) autosomal trisomies, two cases of tetraploidy, one case of monosomy, and a case with two pericentric inversions. The results of this study suggest that patients undergoing assisted reproduction are not at an increased risk for chromosomal abnormalities.