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Updated: Aug 15, 2026

Neonatal Murine Cochlear Explant Technique as an In Vitro Screening Tool in Hearing Research
Published on: June 8, 2017
[Neonatal hearing screening during the first and second day of life]
Z G Del Buono1, F Mininni, M Delvecchio
1Unità di Neonatologiaù, Casa di Cura Santa Maria, Bari, Italy. zoragiovanna.delbuono@tin.it
Insights
Early hearing loss detection in newborns is crucial. Neonatal hearing assessments using transient evoked otoacoustic emissions (TEOAE) are most effective on the second day of life for accurate results.
Area of Science:
- Neonatal screening
- Audiology
- Pediatric health
Context:
- Infant hearing loss can lead to developmental challenges.
- Early identification is key for intervention.
- Transient evoked otoacoustic emissions (TEOAE) are a common screening tool.
Purpose:
- To determine the optimal timing for neonatal hearing screening using TEOAE.
- To compare the efficacy of TEOAE screening on the first versus second day of life.
Summary:
- Hearing loss screening was conducted on 130 newborns using the echo-screen Madsen device (TEOAE).
- Screening on the second day of life demonstrated significantly better test stability, symmetry, and fewer artifacts compared to the first day.
Impact:
- Confirms the second day of life as the most suitable time for neonatal hearing assessment via TEOAE.
- Optimizing screening timing can improve early detection rates and subsequent interventions for hearing loss.
Aim:
Congenital or acquired hearing loss in infanthood has been associated with lifelong deficits in speech and language acquisition, poor school performances and emotional and social maladjustments. The identification of hearing loss through neonatal and infant life can prevent or reduce many of these adverse consequences, permitting early intervention.
Methods:
We performed the screening of hearing loss with a technical device, echo-screen Madsen, based on transient evoked otoacoustic emissions (TEOAE). The screening was carried out in 50 newborns during the 1st day of life and in 80 newborns during the 2nd day of life.
Results:
The 2nd day of life showed a significant better stability of the test and a better symmetry (P<0.001), and less incidence of artefacts (P<0.001).
Conclusions:
The results obtained confirm that the 2nd day of life is the most appropriate time for the neonatal hearing assessment with TEOAE.
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