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Related Experiment Videos

Birth defects in Singapore: 1994-2000.

K H Tan1, T Y T Tan, J Tan

  • 1Department of Maternal Foetal Medicine, Division of Obstetrics and Gynaecology, KK Women's and Children's Hospital, 100 Bukit Timah Road, Singapore 229899. khtan@kkh.com.sg

Singapore Medical Journal
|September 21, 2005
PubMed
Summary

Singapore

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Area of Science:

  • Reproductive Health
  • Pediatric Epidemiology
  • Public Health Surveillance

Background:

  • Birth defects pose a significant global health challenge.
  • Understanding demographic and temporal trends in birth defects is crucial for public health interventions.

Purpose of the Study:

  • To characterize birth defect cases in Singapore from 1994-2000.
  • To analyze trends in incidence, ethnicity, maternal age, and defect types.

Main Methods:

  • Utilized the National Birth Defects Registry (NBDR) data from 1994-2000.
  • Included live births, stillbirths, and abortions, analyzing data by ethnicity, maternal age, and defect classification.
  • Extracted information from various healthcare sources and registries.

Main Results:

  • Reported 7,870 cases (6,278 births, 1,592 abortuses), a rate of 23.99 per 1,000 live births.
  • Observed decreasing incidence of birth defects in live births/stillbirths but increasing abortion rates for defects.
  • Identified higher defect rates in Malays and at the extremes of maternal age; common defects included heart, musculoskeletal, and chromosomal anomalies.

Conclusions:

  • An increasing trend in abortion for birth defects was noted, contrasting with a falling trend in live birth anomalies.
  • Both younger and older maternal age groups faced higher risks for non-chromosomal defects.
  • Advanced maternal age correlated with an increased risk of chromosomal defects.

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