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Diabetes mellitus type 1 in five military aviators: flying with insulin

Dan Carter1, Bela Azaria, Liav Goldstein

  • 1Israeli Aeromedical Center, Tel Hashomer, Israel. carterd@zahav.net.il

Aviation, Space, and Environmental Medicine
|September 22, 2005
PubMed
Abstract

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Insulin: Dosing Regimen and Adverse Effects

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Type I Diabetes III: Clinical Manifestations

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Type I Diabetes I: Introduction

Type 1 diabetes mellitus is a chronic metabolic disorder characterized by an absolute deficiency of insulin resulting from the autoimmune destruction of pancreatic β-cells. Although it can occur at any age, it is most commonly diagnosed in childhood, adolescence, or early adulthood. The loss of insulin production impairs cellular glucose uptake, resulting in persistent hyperglycemia and necessitating lifelong insulin therapy.Autoimmune Destruction of β-CellsThe hallmark of type 1 diabetes is an...
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Type I Diabetes II: Pathophysiology

Type 1 diabetes mellitus arises from an immune-mediated destruction of pancreatic β-cells, resulting in an absolute deficiency of insulin. This process develops in genetically susceptible individuals when autoimmunity, environmental exposures, and immunologic dysregulation converge to trigger a targeted attack on the insulin-producing cells of the pancreas. The β-cells are located within the islets of Langerhans and are essential for regulating blood glucose by facilitating cellular uptake of...