Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Asthma. The mast cell.

S T Holgate1, M K Church

  • 1Immunopharmacology Group, Southampton General Hospital, UK.

British Medical Bulletin
|January 1, 1992
PubMed
Summary
This summary is machine-generated.

Mast cells release histamine and other mediators involved in allergic reactions like asthma. Biochemical signaling pathways trigger the release of pre-formed and newly generated substances from these cells.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

An international Delphi study on the burden of allergic rhinoconjunctivitis and urticaria and the role of bilastine among current treatment options.

Expert review of clinical immunology·2023
Same author

Anaphylaxis to Mepolizumab and Omalizumab in a Single Patient: Is Polysorbate the Culprit?

Journal of investigational allergology & clinical immunology·2020
Same author

Interleukin-17 is a potential player and treatment target in severe chronic spontaneous urticaria.

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology·2020
Same author

Characterization of cowhage-induced pruritus in inflamed and non-inflamed skin.

Journal of the European Academy of Dermatology and Venereology : JEADV·2019
Same author

Comparison of pruritus and sensory qualities induced by capsaicin, histamine and cowhage.

Journal of the European Academy of Dermatology and Venereology : JEADV·2019
Same author

Updosing of bilastine is effective in moderate to severe chronic spontaneous urticaria: A real-life study.

Allergy·2018

Area of Science:

  • Immunology
  • Cell Biology
  • Pharmacology

Background:

  • The historical link between mast cells and asthma dates back to early 20th-century research on histamine.
  • Histamine, identified as a spasmogen for airways, was proposed as a mediator of acute anaphylaxis.
  • Later, histamine was localized to mast cell granules, with IgE identified as crucial for mediator release in allergic reactions.

Purpose of the Study:

  • To explore the historical context of mast cell involvement in asthma.
  • To elucidate the biochemical mechanisms underlying mast cell mediator release.
  • To understand the role of signal transduction in the release of preformed and newly formed mediators.

Main Methods:

  • Historical literature review on mast cells and asthma.

Related Experiment Videos

  • Biochemical analysis of mediator release pathways.
  • Investigation of signal transduction mechanisms in mast cells.

    • Main Results:

    • Mast cells have a long-standing association with asthma pathogenesis.
    • Histamine release from mast cells is a key event in acute allergic responses.
    • Signal transduction pathways mediate both calcium-dependent degranulation and the generation of novel mediators from phospholipid precursors.

    Conclusions:

    • Mast cells are central players in allergic inflammation, particularly in asthma.
    • Understanding mast cell degranulation and mediator synthesis is critical for asthma research.
    • Biochemical signaling pathways are fundamental to the inflammatory cascade initiated by mast cells.