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Related Experiment Videos

MAOA haplotypes associated with thrombocyte-MAO activity.

Mårten Jansson1, Shane McCarthy, Patrick F Sullivan

  • 1Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. marten.jansson@cmm.ki.se

BMC Genetics
|September 22, 2005
PubMed
Summary

Genetic variants in the MAO locus are linked to reduced platelet monoamine oxidase (MAO) activity. This study explored the MAO gene

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Area of Science:

  • Genetics
  • Neuroscience
  • Biochemistry

Background:

  • Investigating the genetic basis of thrombocyte monoamine oxidase (trbc-MAO) activity and its potential link to depression.
  • Focusing on the monoamine oxidase (MAO) gene locus on the X chromosome (Xp11.3-11.4).

Purpose of the Study:

  • To determine if genetic variations in the MAO locus are associated with trbc-MAO activity and depressed states.
  • To analyze the genetic structure of the MAO locus through novel sequencing and haplotype construction.

Main Methods:

  • Sequencing of the MAO gene locus.
  • Validation of genetic variants from public databases.
  • Haplotype construction in a Swedish population sample (N=573).

Main Results:

Related Experiment Videos

  • Identified a significant SNP desert within the MAOB gene.
  • MAOA and MAOB genes form distinct linkage disequilibrium (LD) blocks.
  • Found a significant association between two MAOA haplotypes and reduced trbc-MAO activity.
  • No significant association was observed between MAO locus variants and depressed state.

Conclusions:

  • The MAO locus influences trbc-MAO activity in the studied population.
  • Evidence suggests incomplete X-chromosome inactivation at the MAO locus.
  • A gene-dosage effect may contribute to the higher prevalence of depression in females.