Antisecretory activity of plants used to treat gastrointestinal disorders in Mexico
Claudia Velázquez1, Fernando Calzada, Javier Torres
1Unidad de Investigación Médica en Farmacología de Productos Naturales, Hospital de Pediatría, 2 degrees Piso, Centro Médico Nacional Siglo XXI, IMSS, Col. Doctores, CP 06725, México DF. fercalber1@hotmail.com
Abstract:
Aqueous and methanolic extracts from 26 medicinal plants used in Mexico to treat gastrointestinal disorders were screened to evaluate their antisecretory activity on cholera toxin-induced intestinal secretion in rat jejunal loops model. Extracts were tested at a dose of 300 mg/kg. From 56 samples tested, both extracts from Chiranthodendron pentadactylon, Hippocratea excelsa and Ocimum basilicum were the most potent with inhibition values ranging from 68.0 to 87.6%. On the other hand, the methanolic extract of Geranium mexicanum (aerial parts) and the aqueous extract of Bocconia frutescens showed the highest activity with inhibition values of 93.4 and 86.0%, respectively. The results obtained in this study give some scientific support to the use of the Mexican medicinal plants employed for the treatment of gastrointestinal disorders such as diarrhea.
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