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[Dynamic changes in plasma adrenomedullin levels and effect of enalapril intervention in diabetic rats]
Chun-sheng Xu1, Zhi-liang Li, Hua Zhang
1Department of Cardiology, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China.
Objective:
To observe the dynamic changes of plasma adrenomedullin (ADM) levels and the effect of enalapril intervention in diabetic rats.
Methods:
Fifty-two wistar rats were grouped into 1- and 3-month groups (7 each), both including a control and a streptozotocin-induced diabetic group. The 5-month group was divided into control, diabetic and enalapril-treatment diabetic groups (8 each, the last group receiving oral enalapril treatment at the daily dose of 2 mg/kg from the first to the fifth month after diabetes induction). Blood samples were collected from the heart of the rats at the end of 1, 3 and 5 months for determination of plasma ADM concentrations radioimmunoassay.
Results:
Plasma ADM levels were significantly higher in diabetic rats than in the corresponding control rats in 1- and 3-month groups. ADM levels in the diabetic rats of 5-month group were significantly decreased in comparison with that of 1- and 3-month groups. In 5-month group, plasma ADM levels of enalapril-treated diabetic rats elevated significantly in comparison with that in the control rats and the diabetic rats without enalapril treatment.
Conclusion:
ADM may play an important role in the pathophysiology of diabetes.
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