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Flow Cytometry Analysis of Murine Bone Marrow Hematopoietic Stem and Progenitor Cells and Stromal Niche Cells
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The bone marrow vascular niche: home of HSC differentiation and mobilization

Hans-Georg Kopp1, Scott T Avecilla, Andrea T Hooper

  • 1Weill Medical College of Cornell University, New York, New York, USA.

Physiology (Bethesda, Md.)
|September 22, 2005
PubMed

The bone marrow vascular niche consists of a network of thin-walled and fenestrated sinusoidal vessels whose integrity is maintained and supported by surrounding hematopoietic cells. However, this dependence is highly reciprocal in that the bone marrow vasculature provides not only a conduit for mature hematopoietic cells to the peripheral circulation but also a site where hematopoietic progenitors, especially megakaryocytes, differentiate and set the stage for full reconstitution of hematopoiesis.

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