Prevalence and implications of diastolic dysfunction after subarachnoid hemorrhage

Related Experiment Video

Updated: Aug 15, 2026

Double Direct Injection of Blood into the Cisterna Magna as a Model of Subarachnoid Hemorrhage
10:34

Double Direct Injection of Blood into the Cisterna Magna as a Model of Subarachnoid Hemorrhage

Published on: August 30, 2020

Alexander Kopelnik1, Landis Fisher, Jacob C Miss

  • 1Division of Cardiology, University of California San Francisco Medical Center, San Francisco, CA 94143-0124, USA.

Neurocritical Care
|September 22, 2005
PubMed

Insights

Diastolic dysfunction is common after subarachnoid hemorrhage (SAH), affecting 71% of patients. This condition is linked to pulmonary edema and troponin release, with hypertension and age as key predictors.

Area of Science:

  • Cardiology
  • Neurology
  • Critical Care Medicine

Background:

  • Subarachnoid hemorrhage (SAH) is known to cause electrocardiographic changes, troponin release, and reduced left ventricular ejection fraction.
  • The occurrence and impact of diastolic dysfunction following SAH remain largely uncharacterized.

Purpose of the Study:

  • To determine the prevalence of diastolic dysfunction in patients after SAH.
  • To investigate the association between diastolic dysfunction and cardiac outcomes, including pulmonary edema and troponin release.

Main Methods:

  • Prospective enrollment of SAH patients with serial echocardiographic (including Doppler), clinical, and troponin I data collection.
  • Diastolic function assessment using mitral inflow and pulmonary venous flow Doppler, categorized into normal, impaired relaxation, pseudonormal, or restrictive.
  • Statistical analysis using univariate and multivariate methods to assess relationships between diastolic dysfunction, cardiac outcomes, and clinical predictors.

Main Results:

  • Diastolic dysfunction was prevalent in 71% of 207 evaluable SAH patients.
  • Diastolic dysfunction was a significant predictor of pulmonary edema (OR 3.34) and was associated with troponin release.
  • Older age and a history of hypertension were identified as clinical predictors of diastolic dysfunction.

Conclusions:

  • Diastolic dysfunction is a frequent complication following subarachnoid hemorrhage.
  • Diastolic dysfunction is associated with the development of pulmonary edema and elevated troponin levels in SAH patients.
  • Older age and pre-existing hypertension are risk factors for developing diastolic dysfunction post-SAH.
Abstract

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