Osmotic therapy: fact and fiction

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Updated: Aug 15, 2026

Osmotic Pump-based Drug-delivery for In Vivo Remyelination Research on the Central Nervous System
06:07

Osmotic Pump-based Drug-delivery for In Vivo Remyelination Research on the Central Nervous System

Published on: December 17, 2021

Michael N Diringer1, Allyson R Zazulia

  • 1Neurology/Neurosurgery Intensive Care Unit and Stroke Research Center, Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USA. diringerm@wustl.edu

Neurocritical Care
|September 22, 2005
PubMed

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Osmosis00:47

Osmosis

Approximately 60% to 95% of the weight of living organisms is attributed to water. Therefore, maintaining appropriate water balance within cells is of paramount importance. Osmosis is the movement of water across a semipermeable membrane, such as a cell’s plasma membrane. In living organisms, water plays a crucial role as a solvent—a molecule that dissolves other molecules.Diffusion Versus OsmosisBoth diffusion and osmosis are types of passive transport—cellular transport that does not require...
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Osmosis

Osmosis is the movement of free water molecules through a semipermeable membrane.  The water's concentration gradient across the membrane is inversely proportional to the solutes' concentration. Whereas diffusion transports material across membranes and within cells, osmosis transports only water across a membrane, and the membrane limits the diffusion of solutes in the water. Osmosis is a special case of diffusion.
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Osmosis and Osmotic Pressure of Solutions

A number of natural and synthetic materials exhibit selective permeation, meaning that only molecules or ions of a certain size, shape, polarity, charge, and so forth, are capable of passing through (permeating) the material. Biological cell membranes provide elegant examples of selective permeation in nature, while dialysis tubing used to remove metabolic wastes from blood is a more simplistic technological example. Regardless of how they may be fabricated, these materials are generally...
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Osmotic Pressure

Osmosis is a process where solvent molecules move toward a solution through a semipermeable membrane. As the solution dilutes due to the entry of solvent, it expands. This expansion increases the hydrostatic pressure of the solution. When the hydrostatic pressure equals the osmotic pressure, osmosis stops.Osmotic pressure, denoted by Π, is the minimum pressure needed to prevent the solvent from passing into the solution by osmosis. The van 't Hoff equation calculates the osmotic pressure of an...
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Tonicity in Animals

The tonicity of a solution determines if a cell gains or loses water in that solution. The tonicity depends on the permeability of the cell membrane for different solutes and the concentration of nonpenetrating solutes in the solution within and outside of the cell. If a semipermeable membrane hinders the passage of some solutes but allows water to follow its concentration gradient, water moves from the side with low osmolarity (i.e., less solute) to the side with higher osmolarity (i.e.,...
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Tonicity in Animals

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