Brain tissue salvage in acute stroke

Thrombolysis is the only effective medical therapy of ultra-acute (<3 hours) cerebral ischemia, and it is moving from academic centers to community-based standard therapy in experienced centers. Despite intensive experimental and clinical research, the salvage of brain cells through a host of neuroprotective strategies has not been demonstrated to be efficient. As the imaging and other patient selection methods continue to develop, it may be possible eventually to identify patients who still have viable penumbral brain tissue even after the 3-h window. This review focuses on the possibilities of salvaging acutely ischemic brain tissue and potential reasons for differences in the efficacies of the thrombolytic and neuroprotective therapies.