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CA19-9 as a prognostic factor in inoperable pancreatic cancer: the implication for clinical trials
N R Maisey1, A R Norman, A Hill
1Department of Medicine, Royal Marsden Hospital, Sutton, Surrey, UK.
British Journal of Cancer
|September 22, 2005
Abstract:
In a multivariate analysis of 154 patients receiving chemotherapy, baseline CA19-9 was an independent prognostic factor for overall survival (OS) (HR 1.8; 95% CI: 1.3-2.5, P = 0.0004). The 1-year OS was 19 and 46%, respectively, for patients with a baseline CA19-9 above or below the median value. A fall of 20% in CA19-9 level from baseline was an independent prognostic factor for OS (HR 1.9; 95% CI: 1.1-3.4, P = 0.019).
