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Linear accelerator surgery for meningiomas.

William A Friedman1, Gregory J Murad, Patrick Bradshaw

  • 1Department of Neurosurgery, University of Florida, Gainesville, Florida 32610, USA. friedman@neurosurgery.ufl.edu

Journal of Neurosurgery
|September 24, 2005
PubMed
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Linear accelerator (LINAC) surgery offers high local control rates for benign meningiomas. This radiosurgical treatment resulted in very low permanent morbidity in patients with benign tumors.

Area of Science:

  • Neurosurgery
  • Radiation Oncology
  • Oncology

Background:

  • Meningiomas are tumors that arise from the meninges.
  • Radiosurgery using a linear accelerator (LINAC) is a treatment option for meningiomas.

Purpose of the Study:

  • To review the single-center experience with LINAC radiosurgery for meningiomas.
  • To evaluate the efficacy and safety of LINAC surgery for meningioma treatment.

Main Methods:

  • Retrospective analysis of 210 patients treated with LINAC surgery for meningiomas between 1989 and 2001.
  • Minimum 2-year follow-up for all patients.
  • Actuarial local control rates and complication rates were analyzed based on tumor histology.

Main Results:

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  • High actuarial local control rates were observed: 100% at 1-2 years and 96% at 5 years for benign meningiomas.
  • For atypical meningiomas, control rates were 100% at 1 year, 92% at 2 years, and 77% at 5 years.
  • Malignant meningiomas showed 100% control at 1-2 years but only 19% at 5 years.
  • Temporary complications occurred in 6.2% of patients, and permanent complications in 2.3%.
  • Permanent complications were associated with malignant meningiomas.

Conclusions:

  • LINAC radiosurgery achieves high local control rates for benign meningiomas.
  • The treatment demonstrates a very low rate of permanent morbidity in patients with benign meningiomas.