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Expression of Jun activation domain-binding protein 1 and p27 (Kip1) in thyroid medullary carcinoma

Yasuhiro Ito1, Hiroshi Yoshida, Yasushi Nakamura

  • 1Department of Surgery, Kuma Hospital, 8-2-35, Shimoyamate-dori, Chuo-ku, Kobe, Japan. ito01@kuma-h.or.jp

Pathology
|September 24, 2005
PubMed
Abstract

Insights

Jun activation domain-binding protein 1 (Jab1) overexpression degrades p27, promoting medullary thyroid carcinoma growth. This suggests Jab1 plays a key role in medullary carcinoma progression.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cell Biology

Background:

  • p27 is a key cell cycle inhibitor.
  • Jun activation domain-binding protein 1 (Jab1) promotes carcinoma progression by degrading p27.
  • The role of p27 and Jab1 in medullary thyroid carcinoma is not well understood.

Purpose of the Study:

  • To investigate the expression of p27 and Jab1 in medullary thyroid carcinoma.
  • To determine the relationship between p27 and Jab1 expression and clinicopathological features.
  • To compare the role of Jab1 in medullary thyroid carcinoma with other thyroid carcinoma types.

Main Methods:

  • Immunohistochemical examination of Jab1 and p27 expression in 64 medullary thyroid carcinoma samples.
  • Correlation analysis between protein expression levels and tumor size, plasma calcitonin levels, and p27 localization (nuclear vs. cytoplasmic).

Main Results:

  • Decreased p27 expression was observed in 59.4% of cases and inversely correlated with tumor size and plasma calcitonin levels.
  • Jab1 overexpression was found in 71.9% of cases, a higher incidence than in papillary and follicular carcinomas.
  • Jab1 expression was inversely correlated with p27 expression, with all cases showing only cytoplasmic p27 overexpressing Jab1.

Conclusions:

  • Reduced p27 expression may contribute to medullary thyroid carcinoma growth.
  • Jab1 promotes medullary thyroid carcinoma progression by enhancing p27 degradation.
  • Jab1 appears to play a more significant role in medullary thyroid carcinoma pathogenesis than in papillary or follicular carcinomas.

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