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Modules, multidomain proteins and organismic complexity.

Hedvig Tordai1, Alinda Nagy, Krisztina Farkas

  • 1Institute of Enzymology, Biological Research Center, Hungarian Academy of Sciences, Budapest.

The FEBS Journal
|September 24, 2005
PubMed
Summary
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Protein domains can be classified as mobile or static based on their local environments. Smaller domains are more mobile and form complex multidomain proteins, especially in metazoans due to intronic recombination.

Area of Science:

  • Molecular Biology
  • Evolutionary Biology
  • Bioinformatics

Background:

  • The distinction between mobile protein domains and static domains is currently vague.
  • Quantifying domain mobility is challenging, hindering our understanding of multidomain protein evolution.

Purpose of the Study:

  • To establish a quantitative measure for protein domain mobility.
  • To investigate the relationship between domain mobility, size, and evolutionary propensity to form multidomain proteins.
  • To explore the role of intronic recombination in the evolution of multidomain proteins in metazoans.

Main Methods:

  • Quantifying domain mobility by counting the number of distinct local environments a domain appears in.
  • Analyzing domain mobility across different evolutionary lineages.

Related Experiment Videos

  • Correlating domain size with domain mobility.
  • Investigating the role of intronic recombination in domain shuffling.

    • Main Results:

    • Domain mobility can be accurately measured by the diversity of its local environments.
    • Domain mobility varies significantly across evolutionary lineages.
    • Smaller domains exhibit higher mobility and are more likely to be found in multidomain proteins.
    • Larger domains are more often static, stand-alone units.
    • Intronic recombination in metazoans facilitated the shuffling of protein modules, contributing to novel protein functions and organismic complexity.

    Conclusions:

    • The number of local environments serves as a robust metric for protein domain mobility.
    • Domain size is a key factor influencing domain mobility and its role in protein evolution.
    • Intronic recombination has been a significant driver of protein evolution and complexity in metazoans.