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Related Experiment Videos

Bronchial hyper-responsiveness in selective IgA deficiency.

Athina Papadopoulou1, Despina Mermiri, Sofia Taousani

  • 1Department of Allergology-Pulmonology, Penteli Children's Hospital, P. Penteli, Greece.

Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology
|September 24, 2005
PubMed
Summary

Children with selective IgA deficiency (sIgAD) show a higher prevalence of bronchial hyper-responsiveness (BHR), a condition linked to asthma symptoms. This risk appears associated with mite sensitization.

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Area of Science:

  • Immunology
  • Pediatric Pulmonology
  • Allergy

Background:

  • Secretory IgA (sIgA) is crucial for mucosal defense.
  • Respiratory mucosa in children with selective IgA deficiency (sIgAD) may offer insufficient protection.
  • This deficiency might predispose children to bronchial hyper-responsiveness (BHR) and asthma.

Purpose of the Study:

  • To determine the prevalence of BHR in children with sIgAD.
  • To investigate the relationship between BHR and atopic status in these children.
  • To explore potential risk factors for BHR in sIgAD.

Main Methods:

  • Evaluated 20 children with sIgAD for BHR using inhaled hypertonic saline.
  • Assessed atopy via skin prick testing (SPT) against common aero-allergens.

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  • Compared BHR prevalence with control groups: allergic children (Group B) and healthy children (Group C).

    • Main Results:

    • BHR prevalence was similar in sIgAD (30.0%) and allergic children (35.7%), significantly higher than in healthy controls (5.9%).
    • BHR was associated with current asthma symptoms in sIgAD children.
    • Atopy showed no general association with BHR, except for mite sensitization (p = 0.03).

    Conclusions:

    • Selective IgA deficiency (sIgAD) is a risk factor for developing bronchial hyper-responsiveness (BHR).
    • The development of BHR in sIgAD appears linked to sensitization to mites.
    • These findings highlight the importance of monitoring respiratory health in children with sIgAD.