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Related Experiment Videos

EXPANDER--an integrative program suite for microarray data analysis.

Ron Shamir1, Adi Maron-Katz, Amos Tanay

  • 1School of Computer Science, Sackler Faculty of Exact Sciences, Tel Aviv University, Tel Aviv 69978, Israel. rshamir@tau.ac.il

BMC Bioinformatics
|September 24, 2005
PubMed
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EXPANDER 2.0 is a user-friendly bioinformatics package for analyzing gene expression microarray data. It offers a comprehensive suite of tools for data normalization, clustering, and functional enrichment analysis across multiple organisms.

Area of Science:

  • Bioinformatics
  • Functional Genomics
  • Systems Biology

Background:

  • Gene expression microarrays generate vast datasets, posing challenges for biological knowledge extraction.
  • Bioinformatics tools are needed to integrate and analyze complex microarray data.
  • A need exists for user-friendly, comprehensive software for microarray data analysis.

Purpose of the Study:

  • To introduce EXPANDER 2.0, an integrated software package for gene expression data analysis.
  • To provide biologists with an easy-to-use tool for comprehensive microarray data analysis.
  • To facilitate the understanding of transcriptional networks and biological processes.

Main Methods:

  • EXPANDER 2.0 implements algorithms for data normalization, filtering, clustering, and biclustering.

Related Experiment Videos

  • Includes high-level functional enrichment analysis using Gene Ontology (GO) terms.
  • Performs promoter cis-regulatory element analysis to identify transcription factors.

    • Main Results:

    • EXPANDER 2.0 offers a 'one-stop shop' for diverse microarray data analysis steps.
    • Supports analysis for yeast, worm, fly, rat, mouse, and human datasets.
    • Integrates functional GO data and promoter sequences for comprehensive insights.

    Conclusions:

    • EXPANDER 2.0 is a powerful, integrated tool for microarray data analysis.
    • Its multi-organism support enhances its utility for comparative genomics.
    • The software is freely available to academic users.