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Related Experiment Videos

Cavitation detection during shock-wave lithotripsy.

Michael R Bailey1, Yuri A Pishchalnikov, Oleg A Sapozhnikov

  • 1Center for Industrial and Medical Ultrasound, Applied Physics Laboratory, University of Washington, Seattle, WA 98105, USA. bailey@apl.washington.edu

Ultrasound in Medicine & Biology
|September 24, 2005
PubMed
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Cavitation, or bubble formation, was detected in pig kidney tissue during shock-wave lithotripsy (SWL). This finding is crucial for understanding how SWL causes tissue injury.

Area of Science:

  • Biophysics
  • Medical Imaging
  • Nephrology

Background:

  • Shock-wave lithotripsy (SWL) is a common procedure for kidney stone removal.
  • The mechanisms of tissue injury during SWL are not fully understood.
  • Cavitation, the formation and collapse of bubbles, is a suspected contributor to SWL-induced tissue damage.

Purpose of the Study:

  • To develop and utilize a system for detecting cavitation in pig kidney during SWL.
  • To investigate the occurrence and characteristics of cavitation in renal collecting system (urine) and kidney parenchyma (tissue).
  • To correlate cavitation events with SWL parameters and potential tissue injury.

Main Methods:

  • A Dornier HM3 lithotripter was used for SWL in a pig kidney model.
  • Active cavitation detection via B-mode ultrasound and passive cavitation detection using orthogonal receivers were employed.

Related Experiment Videos

  • Localization of cavitation was confirmed using fluoroscopy, sonography, and thermal marking.

    • Main Results:

    • Cavitation was detected in urine immediately after shock-wave administration.
    • Cavitation in native kidney tissue required hundreds of shock waves to initiate.
    • Cavitation collapse times were similar in tissue and native urine, but shorter in urine with X-ray contrast agent.

    Conclusions:

    • Cavitation occurs within kidney tissue during SWL, not just in urine.
    • This finding provides critical insights into the mechanisms of SWL-induced renal tissue injury.
    • Further research can build upon these findings to optimize SWL safety and efficacy.