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Published on: May 2, 2018
Pathophysiological manifestations in mice exposed to anthrax lethal toxin
Nathan C Culley1, David M Pinson, Anuradha Chakrabarty
1Lab Animal Resources, University of Kansas Medical Center, Kansas City, 66160, USA. nculley@kumc.edu
Abstract:
Pathophysiological changes associated with anthrax lethal toxin included loss of plasma proteins, decreased platelet count, slower clotting times, fibrin deposits in tissue sections, and gross and histopathological evidence of hemorrhage. These findings suggest that blood vessel leakage and hemorrhage lead to disseminating intravascular coagulation and/or circulatory shock as an underlying pathophysiological mechanism.

